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Single-cell transcriptomic and multi-omics analyses have shown that ferroptosis-related gene characteristics are enriched in specific proximal renal tubular subgroups during early type 2 DKD (Tsai et al., 2023

Overexpression or intraperitoneal injection of human transferrin effectively inhibited PR cell death

Upregulation of Histone deacetylase 3 (HDAC3) in pulmonary fibrosis can lead to NRF2 inhibition, and by selectively inhibiting HDAC3 (e.g., using the drug RGFP966), the inhibitory effect on NRF2 can be reduced

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