Unfortunately, they are not very potent since they have a short half-life in vivo
Workplace Health & Safety, 66 (4), 191200
Biomarker and Genetic Considerations in RA Inflammatory Pathways Individual variations in GLP-1 receptor expression and function, influenced by genetic polymorphisms like GLP1R rs6923761, may affect how patients respond to GLP-1 agonists
its rise is delayed compared to the rapid increase of circulating GIP (Herrmann et al., 1995)
Your body is not rejecting tirzepatide
If you are otherwise healthy and eat a well-balanced diet that includes foods rich in, or fortified with vitamin B12, it is unlikely that you need additional B12, either as vitamin tablets or injections