The occluded aqueous cavity housing the Na + -binding site is unusual, and we hypothesise that Na + binding and ordering of solvent within this cavity may stabilise the N-terminal domain and contribute to transporter gating
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How long does reconstituted CJC-1295 DAC remain stable
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A randomized, double-blind, controlled phase II trial in advanced renal cell carcinoma (RCC) demonstrated synergistic anticancer effects with the combination of the glutaminase inhibitor telaglenastat (CB-839) and the mTOR inhibitor everolimus (TelaE), which was well tolerated by patients previously treated with TKIs
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