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228 Its promising multi-pathway effects make quercetin a widely used dietary supplement, 229 and further structural optimization may enhance specificity and stability for therapeutic development

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First, we quantified 141 mono-, di-, and tri- oxygenated lipids using liquid chromatographymass spectrometry across seven membrane lipid classes in BT-549 cells and found the abundance of oxidized membrane lipids was significantly increased in cells treated with ESA ( p = 0.02, Students t-test, one-tailed) (Fig