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Altitude and air pressure At higher altitudes, lower air pressure can cause the rubber stopper to resist needle insertion differently, and drawing water into the syringe may feel slightly different

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Risk differences were attenuated among metformin monotherapy users (2.0 and 4.1) compared with users of 2 or more diabetes medications (5.7 and 4.0) versus SGLT2is and DPP4is, respectively

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It will be interesting to see how these agents reshape obesity and metabolic disease treatment in the coming years