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Today I ended my final Motivational Interviewing (MI) workshop at Sheffield Hallam University School of Business for Nutrition and Public Health Management Masters students with a simple exercise

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Jones B, Sands C, Alexiadou K, Minnion J, Tharakan G, Behary P, et al

General Safety Profile Based on the preclinical dataset and the limited human exposure data: No prominent signal of hepatic, renal, or hematological toxicity at tested doses No prominent cardiovascular safety flag Pregnancy and lactation as with most research compounds, safety not established Long-term effects not characterized What Clinicians Should Actually Tell Patients For patients asking about 5-amino-1MQ, a reasonable response framework: What the compound is: A research-stage small molecule inhibiting NNMT with promising preclinical fat loss data

A clear understanding of the prognosis if no treatment is provided: hyperthyroidism is a progressively worsening condition

The REDEFINE Phase 3 program directly addressed this, showing CagriSema achieved 20.4% weight loss versus lesser results with semaglutide alone, cagrilintide alone, and placebo