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Artery Res

NNMT expression is elevated in adipose tissue in obesity, and NNMT activity is associated with lower adipocyte energy expenditure

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Stacking them addresses two separate metabolic bottlenecks: AMPK suppression (which limits fat oxidation capacity) and NAD+ depletion (which limits mitochondrial function)

Additionally, it does not stimulate the production of IGF-1, has positive effects on the differentiation of adipose mesenchymal stem cells into bone, and was found to promote proteoglycan and collagen production in isolated bovine chondrocytes in an in vitro study