The endothelial cells lining blood vessels may sustain permanent injury, increasing inflammation throughout the circulatory system
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The pivotal cardiovascular trial for oral semaglutide is the SOUL trial published in the New England Journal of Medicine in 2025
Science 355 , 149155 (2017) Bai, X
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However, it can still support significant weight loss and is often slightly more affordable, which may make it a better option for some people