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Los efectos de la semaglutida oral a nivel cardiovascular se estudiaron en el estudio de superioridad doble ciego SOUL que incluy 9.650 pacientes con DM tipo 2 con una duracin media de 14 aos, la inmensa mayora con metformina como tratamiento basal

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The phase 2 semaglutide NASH trial (published in NEJM, 2021) demonstrated NASH resolution in a significant proportion of patients, though fibrosis improvement was modest