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Cell-culture (3T3-L1 adipocytes) 5-Amino-1MQ at 30 M strongly reduced 1-MNA levels in mouse fat cells, confirming NNMT inhibition (Neelakantan et al., Biochemical Pharmacology, 2018)

The FLOW trial showed a 24% reduction in major kidney events in people with type 2 diabetes and CKD, and the SMART trial showed a 52% reduction in urinary albumin leakage, a key marker of kidney damage

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