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The storage lesion is exacerbated in some categories of donors as a function of biology (sex, age) 21 , genetic traits 22,23,24,25 , and lifestyle-associated exposures 26 (comprehensively reviewed in 15,21,27,28

5 NADPH is also an important cofactor in fatty acid synthesis (FAS), which is required for membrane synthesis in proliferating cells, using acetyl CoA as a precursor

All of these are possibilities

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