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The activation of estrogen receptor leads to increased expression of cyclins, and prompts cancer cells to transition from the quiescent phase to the proliferative phase 31 , leading to tumor growth and development

Barkabi-Zanjani S, Ghorbanzadeh V, Aslani M, Ghalibafsabbaghi A, Chodari L

New blood vessel formation could theoretically support tumor growth in those with existing malignancies

Injection Technique Route: Subcutaneous (into the fat layer beneath the skin) Syringe: Insulin syringe, 29 to 31 gauge, 0.5 mL or 1 mL Sites: Abdomen (2 inches from the navel), outer thigh, or upper arm Pinch a fold of skin at the injection site

doi: 10.1002/cld.711 86

The homogenate was then subjected to centrifugation for 10 min at 12,000 g