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For some local diseases related to the skin or nervous system, such as skin nerve injury, local neuropathy, etc., cream formulations can directly deliver drugs to the affected area, increase the concentration of drugs locally, and enhance the therapeutic effect

Clausen et al[24] have reported that GSH plays an important role in the opening of the TJ of intestinal epithelia enhancing the paracellular transport

A distinct feature of these proteins is their structural fold, which includes -helices surrounding a -barrel structure and an overlapping -strand motif

Potential side effects include hypoglycemia (low blood sugar), joint discomfort, water retention, and jaw/facial changes with prolonged use

This specific structure confers celecoxib its selective inhibitory action against COX-2, distinguishing it from non-selective NSAIDs

Dosage modifications or discontinuation may be necessary if abnormalities in laboratory parameters are observed