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Updated June 15, 2026

doi:10.1016/S0140-6736(23)01053-X Abdrabou Abouelmagd A, Abdelrehim AM, Bashir MN, et al

Amorphous solid dispersions, while improving solubility, have a natural tendency to transform into a more stable crystalline form over time, which can lead to a loss of the bioavailability benefit (153)

In a mouse model with CD68-driven macrophage depletion, reduced macrophages lead to an imbalance in M1/M2 polarization, with a predominance of M2 type, inducing spontaneous PAH accompanied by PASMCs proliferation (Zawia et al., 2021)

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