use caution in Lebers hereditary optic neuropathy and discuss risks if youve had B6-related neuropathy or severe kidney disease
While purported to have antioxidant, antidiabetic, and antiaging effects, it has not been approved by the FDA as therapy for any medical disease or condition
Health Canada
Higher NNMT activity means more nicotinamide gets shunted away from NAD+ production
doi:10.1016/j.brainres.2005.03.031
Materials and methods Chemicals and reagents Cytochrome c, reduced glutathione (GSH), oxidized glutathione (GSSG), 5,5-dithio-bis(2-nitrobenzoic acid), cumene hydroperoxide, dimethylnitrosamine (DMNA), erythromycin, dinitrophenylhydrazine (DNPH), lucigenin, glutathione reductase, thiobarbituric acid, NADH, NADPH, coenzyme Q2, antimycin A, sodium succinate, dodecyl maltoside, Hexokinase assay kits, and ATP Bioluminescent cell assay kits were purchased from Sigma-Aldrich Fine Chemicals (St Louis, MO, United States)
