Homozygous mutations are usually seen in groups with marked consanguinity, and homozygous PK deficiency has been well studied in the Amish populations of Pennsylvania and Ohio and also in an isolated fundamental Mormon settlement at the Utah/Arizona border
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In another study, folate losses during vegetable blanching before freezing amounted to about 10% in broccoli, cauliflower, and green beans, 20% in peas, 26% in spinach, and only 1% in yellow beans 396
Preclinical data shows activity over 48 weeks in animal models
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Cell 176 , 7384.e15 (2019)