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It might be time to consider a different approach

3.3 Insulin response In the prediabetes group, treatment with linagliptin did not alter fasting and postload serum insulin levels in prediabetes in both the low and high GLP-1 groups ( Table 3 , Figures 3AC )

[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Guo C, Huang T, Chen A, et al

Although S mimicry of the host coatomer-binding dibasic motif ensures retrograde trafficking to the ERGIC, avoidance of the host-like C-terminal acidic residue is critical for S-coatomer dissociation and therefore incorporation into virions or export for cell-cell fusion