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In Vitro GLP-1R agonist 2 (100 nM, 1,000 nM) activates GLP-1 receptor-mediated cAMP production, with an EC 50 of 101 nM, but exhibits a self-limiting effect at high concentrations [2]

Small-molecule GLP-1 agonists use standard tablet formulation technology with conventional drug product patents

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2 Lipid peroxidation and acetaminophen-induced cell death

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