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Less than 5% body weight loss after 16 or more weeks at a therapeutic dose (10mg or above) constitutes a poor response

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The complicated pathogenesis of PD involves oxidative stress, mitochondrial dysfunction, neuroinflammation, impaired autophagy, and proteostasis imbalance, altogether contributing to neuronal vulnerability

To accurately identify these complex characteristics, statistical analysis is needed, necessitating the profiling of multiple cells of the same type in the same state