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On phase: 20 day protocol (4 injections, one every 5 days)

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Rather than representing a purely cutaneous condition, PsO appears to be a systemic metabolicinflammatory disease in which insulin resistance, adipokine imbalance, and altered gutendocrine signaling contribute to immune dysregulation long before the onset of clinically overt joint involvement (7)

ZIP4 increases expression of transcription factor ZEB1 to promote Integrin 31 signaling and inhibit expression of the gemcitabine transporter ENT1 in pancreatic cancer cells