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Montalban-Bravo G, Benton CB, Wang SA, Ravandi F, Kadia TM, Cortes JE, Daver N, Takahashi K, DiNardo CD, Jabbour EJ, Borthakur G, Konopleva M, Pierce S, Patel KP, Kornblau SM, Kantarjian HM, Young KH, Garcia-Manero G, Andreeff M

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Over time, due to compliance in fascia surrounding cells, malfunction of lymphatic vessels, and increased infiltrate leaving altered capillaries fill the ECM, with protein dense and salt-rich (49) deposits that accumulate in the interstitial space clogging flow through the tissue resulting in hypoxia