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Genetic knock-out of histidine decarboxylase (HDC-KO) has been used to prevent the synthesis of histamine, resulting in histamine deficient mice

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The key is showing a logical progression from drug use to diagnosis

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A significant drug main effect ( p = 0.001), as well as a trend-level drug time-point interaction effect ( p = 0.08) was also detected for GLP-1, suggesting that GLP-1 concentrations were lower under cannabis, compared to the placebo condition

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