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These central effects translate into substantial weight loss - typically 5%-15% of body weight with current GLP-1 RAs - which directly ameliorates hepatic steatosis by reducing adipose tissue mass, reducing hepatic free fatty acid influx, and improving insulin sensitivity

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In the first quarter of 2026, the two drugs generated a combined $12.82 billion in sales, accounting for approximately 65% of Eli Lilly's total revenues

Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer and the cardiovascular system

Clinicians frame it as supportive within a broader metabolic plan built on sleep, nutrition, recovery, and lab-guided evaluation, not as a stand-alone fat-loss shortcut

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