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Daley and colleagues revealed that hyperglycemia triggers Akt2 activation (phosphorylation) in RPE cells, which in turn increases the expression of EMT markers and fibrosis-related proteins via ERK signaling [6]

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[141] applied machine learning to high-throughput NMR metabolomic profile data, and identified nine NMR biomarkers and 19 baseline characteristics which could diagnose ME/CFS with an AUC = 0.83

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