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Materials and Methods Cell lines FlpIn 293 cells (Life Technologies) with low passage number were transfected with empty pcDNA5/FRT vector or pcDNA5/FRT vector containing either wild-type MRP1, wild-type MRP2, or MRP1/MRP2 chimeras and mutants

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This correlation likely stemmed from its systemic effects on inflammation and liver function in critically ill patients (56, 57)

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