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Given the proposed critical role of metabolic alterations, particularly the accumulation of lipid droplets within cardiomyocytes, in driving diastolic dysfunction and HFpEF 56,57 , we examined this in the ZSF1 obese rat model

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Its regulation both at a genetic level (both transcriptional and translational) and a biochemical level (post-translational) is incredibly complex

Sextius P, Warrick E, Prvot-Guguiniat A, et al

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