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Ferroptosis relies primarily on ROS-induced lipid peroxidation, whereas other forms of cell death often result from ROS-induced alterations in protein or DNA function

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Through a series of structure-activity relationship (SAR) studies, the authors optimized the peptide sequence and introduced a C20 fatty diacid via a -glutamic acid linker to the N-terminus

Gallagher CM, Meliker JR

Cytoprotective Mechanism BPC-157s defining characteristic is broad cytoprotection

Gastroenterology 2012