Experts now specify the following fiber targets for those on a GLP-1: 25 g/day of fiber for women, 30 g/day for men and 35 g/day for those with diabetes (Sievenpiper et al 2026) Healthy fats found in olive oil, nuts, seeds, avocado, fatty fish Hydration: 23 L/day for digestion, bowel health, kidneys and energy, up to 4 L/day depending in climate and activity
GLP-1 Medications Are Different: Pharmaceutical GLP-1 medications are synthetic versions engineered to: Last much longer in your body (days instead of minutes) Resist breakdown by enzymes Maintain therapeutic levels continuously Produce stronger, sustained effects than natural GLP-1 Think of it this way: Natural GLP-1: Brief Im full signal during meals GLP-1 medications: Continuous youre satisfied, dont overeat signal all week Types of GLP-1 Medications: Pure GLP-1 Receptor Agonists: These activate only GLP-1 receptors: Semaglutide: Brand names: Wegovy (weight loss), Ozempic (diabetes) Dosing: Once weekly injection Average weight loss: 10-15% of body weight FDA approved: 2017 (Ozempic), 2021 (Wegovy) Liraglutide: Brand name: Saxenda (weight loss), Victoza (diabetes) Dosing: Daily injection Average weight loss: 5-8% of body weight Older, less effective than semaglutide Dulaglutide: Brand name: Trulicity Dosing: Once weekly injection Primarily for diabetes, not typically used for weight loss Dual GIP/GLP-1 Receptor Agonist: Tirzepatide: Brand names: Zepbound (weight loss), Mounjaro (diabetes) Dosing: Once weekly injection Average weight loss: 15-22% of body weight FDA approved: 2022 (Mounjaro), 2023 (Zepbound) Most effective weight loss medication available What Makes Tirzepatide Different: Tirzepatide activates two hormone receptors instead of one: GLP-1 Effects (same as semaglutide): Appetite suppression Slowed stomach emptying Increased insulin secretion Reduced glucagon production Plus GIP Effects: Enhanced insulin response Improved insulin sensitivity Effects on fat metabolism Additional appetite suppression Result: 5-7% more weight loss than semaglutide alone, making tirzepatide the most effective option
SeekPeptides has compiled the research, the clinical data, and the practical guidance that thyroid patients need to make informed decisions
Wellness providers like River Oaks Drip Spa offer IV therapy options designed to support metabolism, hydration, and overall wellness for patients on GLP-1 medications
Back to ACR Convergence 2025 ACR Meeting Abstracts -
13, 2022, p
