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Proton-pump inhibitors (e.g., omeprazole, esomeprazole, and lansoprazole), used to treat Zollinger-Ellison syndrome and gastroesophageal reflux disease (GERD), markedly decrease stomach acid secretion required for the release of vitamin B 12 from food but not from supplements

Fridge door compartments cycle between 4 C and 12 C every time the door opens, which is acceptable for short-term storage but not ideal

It does not replace the organisations own assessment of its procedures, exposure routes and controls

Safety analysis The incidence of adverse events in the two arms will be compared using the Pearson Chi-squared test or Fishers Exact test as required

If you have pernicious anemia, make sure youre using the methylcobalamin form of B12

The cancelled 2015 Phase I trial (NCT02637284) was almost certainly abandoned for this reason rather than buried by a regulator