In this review, GLP-1 RAs effectively reduce weight and improve glucose metabolism in obese women with PCOS
The primary endpoint will be HbA1c change
Its principal molecular activity is G-actin sequestration via the conserved 'LKKTET' actin-binding motif in the N-terminal region
[1] Whilst Ozempic has demonstrated significant efficacy in glycaemic control and, in adults with type 2 diabetes and established cardiovascular disease, cardiovascular risk reduction, gastrointestinal side effects are amongst the most commonly reported adverse reactions
However, despite the short-term adverse effects on thyroid autoimmunity, raising iodine intake from a deficient to an optimal intake-level ultimately results in the decreased prevalence of AITD
Its ability to stimulate growth hormone release results to increased muscle protein synthesis and greater retention of lean body mass while also supporting reduction of body fat