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Animal models are indispensable for mechanistic exploration but cannot fully replicate the long-term, multifactorial progression of human neurodegenerative diseases

Challenges include gastrointestinal side effects, nutritional deficiencies due to calorie reduction, muscle and bone loss, low long-term adherence with subsequent weight regain, and high costs, resulting in low cost-effectiveness

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Other sleep disorders, such as restless leg syndrome or insomnia, can also contribute to night sweats by disrupting the normal sleep cycle

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Int J Environ Res Public Health 20(2):1070