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Hepatic-specific Zip8 KO mice showed significantly lower hepatic Mn levels (Powers et al., 2023), as did Zip8 loss-of-function mutations (Sunuwar et al., 2020), while bile Mn levels were increased by two-fold (Sunuwar et al., 2020)

Andrologia 21, 568575

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In general, follow these guidelines: Ozempic injection pens should be kept in the refrigerator, but once in use you can keep them at room temperature or in the fridge for up to 56 days