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Individuals taking warfarin or other anticoagulants require careful monitoring, as CoQ10's chemical structure resembles vitamin K, which plays a key role in blood clotting

The consequences of NNMT inhibition over months or years are unknown

Thats controlled human data, not an animal model

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Individual tolerance varies considerably, and many patients successfully continue treatment with minimal or manageable symptoms, particularly when appropriate dose escalation and dietary modifications are implemented