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Targeting the D1R-GHSR1a dimer for treatment of Parkinsons disease A standard treatment for Parkinsons disease typically involves the use of drugs that restore dopamine concentrations from the low levels caused by the loss of dopaminergic neurons in the substantia nigra (Mercuri and Bernardi, 2005)

Stress, toxins, and poor sleep quickly deplete glutathione stores

doi: 10.1016/j.devcel.2018.01.003 63 KimJSuhYHChangKA

Under oxidative stress, these residues are prone to oxidation in sulfenic acid, which efficiently reacts with GSH leading to form GSSG which is catalytically reduced back to GSH by the NADPH dependent glutathione reductase (GR)

Kimbrough et al

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