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It is partly the reduction in total protein intake that naturally accompanies the appetite suppression

Valine can be degraded into simpler compounds in the body, but in people with a rare genetic condition called maple syrup urine disease, a faulty enzyme interrupts this process and can prove fatal if untreated

Qualifying criteria include BMI greater than 27 with prediabetes or established cardiovascular disease, or BMI over 30 with uncontrolled hypertension, advanced kidney disease, or heart failure

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Any dietary surplus is oxidized to sulfate and excreted in the urine or is stored as glutathione (GSH)