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Notably, no cases of clinically significant hypoglycemia, medullary thyroid cancer, or C-cell hyperplasia were reported in published trial data
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Dhein S, Salameh A
Rare but significant concerns include gallstone disease (12%), especially in the context of rapid weight loss, and acute pancreatitis ( 10% weight loss aligns with lifestyle guidelines and might amplify the effects of secondary agents targeting inflammation or fibrosis
Genetic modifiers of liver injury in hereditary liver disease
Key trial findings Up to 16.3% weight loss at the 180 mg dose Results measured after around 11 months of treatment Low discontinuation rates (~23%) due to side effects Phase 3 trials planned later this year These results are particularly notable because oral GLP-1 drugs have historically struggled to match the effectiveness of injectable therapies
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