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HOLST: So there's something that is much more important, and that is to emphasize that the advice that you need to have when you start this therapy because you lose weight, but you also lose lean body mass
Step 4: Consider the format
The LEAD (Liraglutide Effect and Action Diabetes) program reported that liraglutide significantly reduced weight and improved glycated haemoglobin (HbA1c) compared to placebo/standard of care [24,25,26,27,28,29,30,31]
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Sartorelli & David G
In the EDICT trial, 221 drug-naive patients with recently diagnosed T2D were randomized to initial simultaneous therapy comprising a combination of agents known to improve insulin secretion and sensitivity (metformin, pioglitazone, and exenatide) or treatment with sequential therapy (i.e., an escalating dose of metformin followed by sequential addition of a sulfonylurea and insulin glargine)
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