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Further studies confirmed that aerobic exercise significantly upregulated the expression of PPAR- in cardiac microvascular ECs of aging MI/R-injured mice, which upregulated the expression of FUNDC1 and, in turn, upregulated the expression of LC3-II proteins and downregulated the level of p62 proteins

No peer-reviewed human clinical trial data on 5-Amino-1MQ efficacy or safety appears to be available in published literature, representing a significant evidence gap

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