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Emerging evidence suggests that ketone bodies such as BHB may play a direct role in reducing inflammation, although more human studies are needed to confirm these pathways
Grunstein RR, Taylor R, Shinde S, Dunn JP, Bednarik J, Stefanski A, Falcon B
In general, the expression of HSP70 has become a major interest of studies because of its role in modulating inflammatory immune response and cytoprotection under stress conditions in a wide diversity of experimental injury models [73, 109]
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NNMT (nicotinamide N-methyltransferase) is the enzyme 5-Amino-1MQ inhibits, and tissue expression varies significantly across organs: adipose tissue shows 812 higher NNMT activity than skeletal muscle, which is why subcutaneous injection near adipose depots produces localised effects rodent models couldn't predict
