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Cytotoxic effects have been reported for some cathelicidins against eukaryotic cells (hematopoietic cell lines, erythrocytes, and proliferating cells) [103, 104]

The dose escalation schedule will follow the same four-weekly increments used initially: 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, and finally 2.4 mg maintenance dose

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Long-term treatment of cultured cells with lithium and valproate also enhanced cellular respiration rate and mitochondrial function as determined by mitochondrial membrane potential and oxidation [58]