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Another study exploring the association between folate and symptoms of schizophrenia indicated that low folate was associated with negative symptoms severity in schizophrenia subjects 94

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While oral DFP has a risk of hematological toxicity (Ruivard and Lobbes, 2023), oral DFX can cause hepatic and renal toxicity and gastrointestinal bleeding with chronic use (Yusuf et al., 2023)