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Nausea management is the main practical challenge

Mitochondrial dysfunction: NRF2 also orchestrates mitochondrial proteins such as superoxide mutase 1 (SOD1), which scavenges mitochondrial ROS and RNS to protect the mitochondrial respiratory chain from oxidative insults (Gumeni et al., 2021) and protein deglycase DJ-1 (PARK7), which maintains mitochondrial complex I activity and the mitochondrial membrane potential, two critical indicators for mitochondrial health (Hayashi et al., 2009

Notably, there was up to a 27% reduction in visceral fat, the type that matters most for long-term health benefits

Cell Transplantation

Long-term lifestyle changes remain essential

A.YoungA.GillR.AburasaynH.et al (2021)