However, patients should be advised to report symptoms suggestive of liver injury, including: Persistent nausea or vomiting unrelated to expected GI side effects Right upper quadrant abdominal pain (which may also indicate gallbladder disease, a known risk with GLP-1 therapy) Jaundice (yellowing of skin or eyes) Dark urine or pale stools Unexplained fatigue or malaise Clinicians should maintain a low threshold for investigating these symptoms with comprehensive liver function tests, including ALT, AST, alkaline phosphatase, bilirubin, albumin, and INR/prothrombin time
In patients with TAO, the oxidative stress response is characterized by elevated levels of SOD and lipid peroxides, whereas GSH concentrations decrease within the orbital connective tissue (340)
Over the past five years, The Miss Brand Inc
10.1111/j.1365-2125.2012.04425.x [DOI] [PMC free article] [PubMed] [Google Scholar] 25.Xiao J, Hgger P
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Image: IPGGutenbergUKLtd/Getty Images About the Author Julie Corliss, Executive Editor, Harvard Heart Letter About the Reviewer Eric G