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It contains a hydrophobic pocket which binds Leu, Ile, or Phe residues 17 from peptides adopting an extended conformation interacting through hydrogen bonds with a conserved glutamine (Q89)

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Throughout these disease processes, ROS-mediated impairment of antioxidant defense systems and pro-survival pathways further amplifies the neurodegeneration cascade [339]

pH jumping method This is another solvent-free method that was first reported by Hauser and colleagues where SUVs were formed because of pH jump to MLVs [40, 48]