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Given the importance of glucose and glutamine metabolism in pancreatic cancer cells, it is not surprising that gemcitabine resistance is closely associated with metabolic status, including cellular glucose and glutamine levels
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These requirements of man for methionine, and the sparing effects of cysteine, determined in young healthy volunteers in 1955 by Rose et al are still accepted today, in spite of indications that they may not represent universal values [5]
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Interestingly, symptoms experienced by PBH patients in the postprandial state show some similarities to those in individuals who have serotonin syndrome, a condition induced by SSRIs and other serotoninergic medications (54) and manifested by confusion, sweating, tremors, and, in more severe cases, seizures (55)
