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Semaglutide resulted in: 3.6% weight loss at 3 months 5.8% weight loss at 6 months 8.3% weight loss at 12 months Meanwhile, tirzepatide showed: 5.9% weight loss at 3 months 10.1% weight loss at 6 months 15.3% weight loss at 12 months Soon after starting a weight loss injection, you should notice changes to your hunger, cravings, and food preoccupations