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[22] Wang X, Shen Y, Wang S, et al

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In patients that completed 5 weeks of therapy in a controlled flexible dose pediatric adjunctive to stimulants study, 19% of patients treated with clonidine hydrochloride extend-release tablet+stimulant versus 7% treated with placebo+stimulant reported somnolence

doi:10.1046/j.1365-313x.2001.01071.x

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Approximately 0.1-0.2% of the body's total B12 stores are lost daily through urinary and faecal excretion , representing a relatively slow depletion rate compared to other water-soluble vitamins