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The protective role of Achyranthes aspera extract against cisplatin-induced nephrotoxicity by alleviating oxidative stress, inflammation, and PANoptosis

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2 Human -cell lipotoxicity in vivo Transportation of fatty acids throughout the body occurs via the blood, in either an esterified (predominantly as triglycerides) or non-esterified (as FFA) form, but it is the latter that are thought to be pathogenic in T2D ( de novo fatty acid synthesis, reduced FFA clearance, and enlarged adipocytes releasing more FFA [as reviewed by ( In vivo studies assessing the relationship between FFA and human -cell function report that high FFA concentrations are associated with a decline in insulin secretion ( in vivo remains challenging

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