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Many preclinical studies have demonstrated that the expression of key enzymes for GSH synthesis (GCL, SLC7A11, GS) and GSSG reduction-related enzymes (G6PD, NADPH, and GR) is downregulated in myocardium exposed to pathological factors [40, 43,44,45,46,47,48,49,50]

Body aches refer to generalized muscle pain or soreness, while fatigue is a persistent feeling of tiredness or lack of energy that does not improve with rest

Due to the limited total amount of TGs in HeLa cells, the minor TGs loss by Cr GPDH expression in HeLa cells can be easily compensated by de novo lipogenesis from acetyl-CoA

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It can also be activated directly by essential amino acids such as leucine (Kimball et al ., 1999)

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