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Other types of GPXs have been shown to be expressed in the cochlea, for instance, GPX2 protein is greatly increased in chicken utricle HC expression during HC differentiation (Zhu et al., 2019) and cisplatin injury leads to the decreased GPX2 expression in HEI-OC1 cells (Youn et al., 2017

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Nuclear factor erythroid 2-related factor 2 (Nrf2) functions as a transcription factor and a central regulator of the bodys oxidative stress response 11,12 , so that activating Nrf2 holds promise as an effective therapeutic strategy in OA